Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma.

@article{Fowles2015ComparativeAO,
  title={Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma.},
  author={Jared S. Fowles and Cathrine L. Denton and Daniel L. Gustafson},
  journal={Veterinary and comparative oncology},
  year={2015},
  volume={13 3},
  pages={288-304}
}
The lack of advanced animal models of human cancers is considered a barrier to developing effective therapeutics. Canine and human melanomas are histologically disparate but show similar disease progression and response to therapies. The purpose of these studies was to compare human and canine melanoma tumours and cell lines regarding MAPK and PI3K/AKT signalling dysregulation, and response to select molecularly targeted agents. Pathway activation was investigated via microarray and mutational… CONTINUE READING
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