Comparative analysis of IRF and IFN‐alpha expression in human plasmacytoid and monocyte‐derived dendritic cells

@article{Izaguirre2003ComparativeAO,
  title={Comparative analysis of IRF and IFN‐alpha expression in human plasmacytoid and monocyte‐derived dendritic cells},
  author={Alexander G Izaguirre and Betsy J. Barnes and Sheela B. Amrute and W-S Yeow and Nicholas J. Megjugorac and Jihong Dai and Di Feng and Eugene Chung and P. M. Pitha and Patricia Fitzgerald-Bocarsly},
  journal={Journal of Leukocyte Biology},
  year={2003},
  volume={74}
}
Plasmacytoid dendritic cells (PDC) produce high levels of type I IFN upon stimulation with viruses, while monocytes and monocyte‐derived dendritic cells (MDDC) produce significantly lower levels. To find what determines the high production of type I IFN in PDC, we examined the relative levels of IRF transcription factors, some of which play critical roles in the induction of IFN. Furthermore, to determine whether the differences could result from expression of distinct IFNA subtypes, the… 
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TLDR
It is observed that short-term interruptions of antiretroviral therapy are sufficient to result in significantly reduced IFN-α production by PDC in vitro in response to CpG A ligands or inactivated HIV particles, which suggests diminished function in vitro is likely a consequence of prior activation via type I interferons or HIV virions in vivo.
Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo
TLDR
Investigation of type I IFN production triggered by RSV or influenza A virus infection of BALB/c mice found that while both viruses induced IFN-α/β production by pDCs in vitro, only influenza virus infection could stimulate type IIFN synthesis by p DCs in vivo.
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