Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.

@article{Franken1996ComparativeAI,
  title={Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.},
  author={M. A. M. Franken and Odile Devergne and Michael B. Rosenzweig and B L Annis and Elliott Kieff and Fred Wang},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={7819-26}
}
Nonhuman primates are naturally infected with a B-lymphotropic herpesvirus closely related to Epstein-Barr virus (EBV). These simian EBV share considerable genetic, biologic, and epidemiologic features with human EBV, including virus-induced tumorigenesis. However, latent, transformation-associated viral genes demonstrate marked sequence divergence among species despite the conserved functions. We have cloned the latent membrane protein 1 (LMP1) homologs from the simian EBV naturally infecting… CONTINUE READING
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