Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: a crucial role of CD25(-) FOXP3(-) T cells.

@article{Kakita2012ComparativeAO,
  title={Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: a crucial role of CD25(-) FOXP3(-) T cells.},
  author={Naruyasu Kakita and Tatsuya Kanto and Ichiyo Itose and Shoko Kuroda and Michiyo Inoue and Tokuhiro Matsubara and Koyo Higashitani and Masanori Miyazaki and Mitsuru Sakakibara and Naoki Hiramatsu and Tetsuo Takehara and Akinori Kasahara and Norio Hayashi},
  journal={International journal of cancer},
  year={2012},
  volume={131 11},
  pages={
          2573-83
        }
}
Regulatory T cells (Tregs) play pivotal role in cancer-induced immunoediting. Increment of CD25(high+) FOXP3+ natural Tregs has been reported in patients with hepatocellular carcinoma (HCC); however, the involvement of other type of Tregs remain elusive. We aimed to clarify whether FOXP3- Tregs are increased and functionally suppressive or not in patients with HCC. We enrolled 184 hepatitis C-infected patients with chronic liver diseases or HCC, 57 healthy subjects and 27 HCC patients with… CONTINUE READING
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