Comparative analyses of megakaryocytes derived from cord blood and bone marrow.

  title={Comparative analyses of megakaryocytes derived from cord blood and bone marrow.},
  author={Rika Miyazaki and Hajime Ogata and Toyotaka Iguchi and Shinji Sogo and Taketohi Kushida and Toshiro Ito and Muneo Inaba and Susumu Ikehara and Yoshimi Kobayashi},
  journal={British journal of haematology},
  volume={108 3},
Thrombocytopenia is typically observed in patients undergoing cord blood transplantation. We hypothesized that delayed recovery of the platelet count might be caused by defects in the megakaryocytic differentiation pathway of cord blood progenitors. To test this hypothesis, we compared the features of in vitro megakaryocytopoiesis between cord blood progenitors and those in bone marrow cells after isolation of CD34+ cells as progenitors. The proliferative responses of the progenitors in cord… CONTINUE READING


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