Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.

@article{Reddy1995ComparativeAO,
  title={Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.},
  author={Thipparthi Raghavendar Reddy and Guenter Kraus and Osamu Yamada and David J. Looney and Modem Suhasini and Flossie Wong-Staal},
  journal={Journal of virology},
  year={1995},
  volume={69 6},
  pages={3549-53}
}
Virion infectivity factor (vif), a gene found in all lentiviruses, plays an essential role in virus replication in certain target cells. We examined the replication competence of the human immunodeficiency virus type 2 (HIV-2) vif mutant in different T-cell lines and primary cells in comparison with that of the HIV-1 vif mutant. Both mutant viruses were unable to replicate in peripheral blood-derived mononuclear cells but replicated with wild-type efficiency in certain T-cell lines, such as… CONTINUE READING