Comparative analyses of bidirectional promoters in vertebrates

@article{Yang2008ComparativeAO,
  title={Comparative analyses of bidirectional promoters in vertebrates},
  author={Mary Yang and James Taylor and Laura Elnitski},
  journal={BMC Bioinformatics},
  year={2008},
  volume={9},
  pages={S9 - S9}
}
Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ancestral history of the promoter regions. Our mapping of bidirectional promoters from humans to fish shows that many such promoters emerged after the divergence of chickens and fish. Furthermore, annotations of promoters in deep phylogenies enable detection of missing data or… CONTINUE READING
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