Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery.

@article{Mimeault1991ComparativeAA,
  title={Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery.},
  author={Murielle Mimeault and Alain Fournier and Yvan Dumont and Serge St-Pierre and R{\'e}mi Quirion},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={258 3},
  pages={1084-90}
}
Recent data have suggested that N-truncated human calcitonin gene-related peptide (hCGRP) fragments such as hCGRP8-37 and hCGRP12-37 behave as competitive antagonists in certain bioassays. The present study was undertaken to determine which amino acid residues between positions 8 to 12 are directly involved in ensuring high affinity and antagonist properties at CGRP receptors. In brain, atrium and vas deferens membrane preparations, hCGRP8-37 and hCGRP9-37 demonstrated affinities similar to or… CONTINUE READING

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