Comparative activity of cefodizime and ceftriaxone against respiratory pathogens in an in vitro pharmacodynamic model simulating concentration-time curves.

@article{Blandino2000ComparativeAO,
  title={Comparative activity of cefodizime and ceftriaxone against respiratory pathogens in an in vitro pharmacodynamic model simulating concentration-time curves.},
  author={Giovanna Blandino and Ilaria Milazzo and Rosario Musumeci and Vito Mar Nicolosi and Annamaria Speciale and G Nicoletti},
  journal={Journal of chemotherapy},
  year={2000},
  volume={12 6},
  pages={503-8}
}
The duration of time that serum levels are above the minimum inhibitory concentration (MIC; T >MIC) seems to be an important pharmacodynamic parameter for beta-lactams. The aim of this study was to evaluate the bactericidal activity of cefodizime and ceftriaxone in a pharmacokinetic model mimicking the concentrations in bronchial mucus and in serum (total and free) obtained at 2, 4, 8, 12 and 24 h, after 1 g i.m. administration once daily. The species investigated were respiratory pathogens (1… CONTINUE READING