Comparative Trial of Serotonin Antagonists in the Management of Migraine

@article{Lance1970ComparativeTO,
  title={Comparative Trial of Serotonin Antagonists in the Management of Migraine},
  author={J. Lance and M. Anthony and B. Somerville},
  journal={British Medical Journal},
  year={1970},
  volume={2},
  pages={327 - 330}
}
  • J. Lance, M. Anthony, B. Somerville
  • Published 1970
  • Medicine
  • British Medical Journal
  • The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than “half improved.” The corresponding figures for BC105 were 10% and 40%, respectively. The results with BC105 were significantly better than those with placebo (P<0·02). The total improvement rates with… CONTINUE READING
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