• DOI:10.1136/bmj.2.5705.327
Corpus ID: 22489182

Comparative Trial of Serotonin Antagonists in the Management of Migraine

@article{Lance1970ComparativeTO,
  title={Comparative Trial of Serotonin Antagonists in the Management of Migraine},
  author={J. Lance and M. Anthony and B. Somerville},
  journal={British Medical Journal},
  year={1970},
  volume={2},
  pages={327 - 330}
}

J. Lance, M. Anthony, B. Somerville

Published 1970

Medicine

British Medical Journal

The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than “half improved.” The corresponding figures for BC105 were 10% and 40%, respectively. The results with BC105 were significantly better than those with placebo (P<0·02). The total improvement rates with… CONTINUE READING

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