Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program

@inproceedings{Knapp2013ComparativeTP,
  title={Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program},
  author={Dunja Knapp and Herbert Schulz and Cynthia Alexander Rasc{\'o}n and Michael Volkmer and Juliane Scholz and Eugen Nacu and Mu Le and Sergey N Novozhilov and Akira Tazaki and Stephanie Protze and Tina Jacob and Norbert Hubner and Bianca H Habermann and Elly M. Tanaka},
  booktitle={PloS one},
  year={2013}
}
Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes. By clustering the expression profiles of these samples, we could detect three distinguishable phases of gene expression - early wound… CONTINUE READING
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