Comparative Transcriptional Network Modeling of Three PPAR-α/γ Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes

Abstract

AIMS To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or a combination of pioglitazone (Pio; PPAR-γ agonist) and fenofibrate (Feno; PPAR-α agonist) in human hepatocytes. METHODS AND RESULTS Gene expression microarray… (More)
DOI: 10.1371/journal.pone.0035012

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@inproceedings{Deehan2012ComparativeTN, title={Comparative Transcriptional Network Modeling of Three PPAR-α/γ Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes}, author={Renee Deehan and Pia Maerz-Weiss and Natalie L. Catlett and Guido Steiner and Ben Wong and Matthew B. Wright and Gil Blander and Keith O. Elliston and William Ladd and Maria Bobadilla and Jacques Mizrahi and Carolina Haefliger and Alan D. Edgar}, booktitle={PloS one}, year={2012} }