Comparative Tolerability and Harms of Individual Statins: A Study-Level Network Meta-Analysis of 246 955 Participants From 135 Randomized, Controlled Trials

@article{Naci2013ComparativeTA,
  title={Comparative Tolerability and Harms of Individual Statins: A Study-Level Network Meta-Analysis of 246 955 Participants From 135 Randomized, Controlled Trials},
  author={Huseyin Naci and Jasper Jan Brugts and Tony Ades},
  journal={Circulation: Cardiovascular Quality and Outcomes},
  year={2013},
  volume={6},
  pages={390–399}
}
  • Huseyin Naci, Jasper Jan Brugts, Tony Ades
  • Published 2013
  • Medicine
  • Circulation: Cardiovascular Quality and Outcomes
  • Background—Our objective was to estimate the comparative harms of individual statins using both placebo-controlled and active-comparator trials. Methods and Results—We systematically reviewed randomized trials evaluating different statins in participants with and without cardiovascular disease. We performed random-effects pairwise and network meta-analyses to quantify the relative harms of individual statins. We included 55 two-armed placebo-controlled and 80 two- or multiarmed active… CONTINUE READING

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