Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie

@inproceedings{Houston2015ComparativeSO,
  title={Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie},
  author={Fiona E Houston and Wilfred Goldmann and James H. Foster and Lorenzo Gonz{\'a}lez and M Haddad Jeffrey and Nora Hunter and A E Kincaid},
  booktitle={PloS one},
  year={2015}
}
Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to experimental challenge with various scrapie strains and with bovine spongiform encephalopathy (BSE), which affects cattle and has been accidentally transmitted to a range of other species, including man. Incidence and incubation period of clinical disease in sheep following inoculation is controlled by the PRNP gene, which has different alleles defined on the basis of polymorphisms, particularly at codons 136… CONTINUE READING
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