Comparative Study of the in Vitro Protective Effects of Several Antioxidants on Elongation Factor 2 under Oxidative Stress Conditions

@article{Arguelles2010ComparativeSO,
  title={Comparative Study of the in Vitro Protective Effects of Several Antioxidants on Elongation Factor 2 under Oxidative Stress Conditions},
  author={Sandro Arguelles and Mercedes Cano and Alberto Machado and Antonio Ayala},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2010},
  volume={74},
  pages={1373 - 1379}
}
One of the biochemical pathways affected by aging in all organisms is protein synthesis. Previous reports from our laboratory have indicated that the elongation step is specially affected by aging as a consequence of alterations in elongation factor-2 (eEF-2). In the present work, we studied in vitro the effectiveness of several individual nutritional antioxidants in protecting the levels of hepatic eEF-2 subjected to oxidative stress induced by cumene hydroperoxide. The in vitro system… 
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