Comparative Study of Cd8+T-Cell Count and Leukopoietin Levels in Human Immunodeficiency.
- V. Kumar, A. K. Abbas, J. C. Aster
This study was carried out to determine the comparative study of cd8+ cell count and leukopoietin levels in human immunodeficiency virus infection in Umuahia, Nigeria. A total number of ninety (90) subjects within the age of 18-60 years were used for the study. The subjects were divided into three (3) groups of thirty (30) subjects in each group. Group I comprised of control subjects. Group II were HIVsubjects not on therapy, and group III were AIDSsubjects not on therapy. Blood samples were collected into commercially prepared dipotassium EDTA vacutainer for both test and control subjects after informed consent. These were used in determining their CD8+cells counts and Leukopoietin levels. After the analyses of the blood samples, the following results were observed. The CD8+cells count of group II (967 +198 cells/ml) was significantly higher than that of group I (586+81 cells/ml) while the CD8+cells count of group III CD8+ (1086+228 cells/ml) showed a statistically higher level when compared with those of groups I & II at p<0.05. The level of leukopoietin of group II (1.9+0.9) was slightly higher than that of group I (1.2+0.9) but not statistically significant at P<0.05. The Leukopoietin of group III (5.4 + 1.5) was statistically higher when compared with those of groups I (1.2 +0.9) and II (1.9 + 0.9) respectively there was a strong positive correlation between CD8+ cell counts and leukopoietin levels as observed from analysis. The results therefore showed that following HIV infection there is expansion of CD8+ cells with increased production of leukopoietin.