Comparative Studies on Solubility and Dissolution Enhancement of Different Itraconazole Salts and Their Complexes

  title={Comparative Studies on Solubility and Dissolution Enhancement of Different Itraconazole Salts and Their Complexes},
  author={Hemalatha Bagavatula and Srinivas Lankalapalli and V. S. Vinai Kumar Tenneti and Naga Malleswara Rao Beeraka and Bhanu Teja Bulusu},
Itraconazole is a potent triazole antifungal drug which has low solubility at physiological pH conditions. Itraconazole is weakly basic (pKa =3.7) and highly hydrophobic drug. It is categorized as a BCS class II drug. The main objective of the present investigation was to improve the solubility of itraconazole, by preparation of salt forms itraconazole hydrochloride, mesylate and besylate by using addition reaction with hydrochloric acid, methane sulphonic acid and benzene sulphonic acid… CONTINUE READING


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