Comparative Single‐Dose Kinetics of Oxazolam, Prazepam, and Clorazepate: Three Precursors of Desmethyldiazepam

@article{Ochs1984ComparativeSK,
  title={Comparative Single‐Dose Kinetics of Oxazolam, Prazepam, and Clorazepate: Three Precursors of Desmethyldiazepam},
  author={Hermann R. Ochs and David J Greenblatt and B. Verburg-Ochs and Ann Locniskar},
  journal={The Journal of Clinical Pharmacology},
  year={1984},
  volume={24}
}
Abstract: Twelve healthy volunteers received a single 40‐mg oral dose of the benzodiazepine derivative oxazolam, which serves primarily as a precursor of the active substance desmethyldiazepam (DMDZ). Concentrations of DMDZ were measured in multiple serum samples drawn for up to two weeks after the dose. Peak serum DMDZ concentrations averaged 115 ng/ml, measured at 8.6 hours after dosage. Mean DMDZ elimination half‐life averaged 61 hours. Three of the subjects also received 40 mg each of… 
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