Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension

  title={Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension},
  author={Caroline O’Connell and D. Amar and A. Boucly and L. Savale and X. Jaı̈s and Marie-Camille Chaumais and D. Montani and M. Humbert and G. Simonneau and O. Sitbon},
  journal={Drug Safety},
  • Caroline O’Connell, D. Amar, +7 authors O. Sitbon
  • Published 2016
  • Medicine
  • Drug Safety
  • Prostacyclin (PGI2) is a prostaglandin derived from arachidonic acid in the endothelium and smooth muscle which causes vasodilation, inhibits platelet aggregation, and has anti-inflammatory, anti-thrombotic and anti-proliferative effects. In pulmonary arterial hypertension (PAH), PGI2 levels and PGI2 synthase expression are reduced, contributing to the vasoconstriction and vascular smooth muscle cell proliferation seen in the disease. Based on these findings, PGI2 analogues were developed to… CONTINUE READING
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