Comparative Safety Profile of Levofloxacin in 2523 Children With a Focus on Four Specific Musculoskeletal Disorders

@article{Noel2007ComparativeSP,
  title={Comparative Safety Profile of Levofloxacin in 2523 Children With a Focus on Four Specific Musculoskeletal Disorders},
  author={Gary J Noel and John S Bradley and Ralph E. Kauffman and Ciar{\'a}n M. Duffy and Peter G. Gerbino and Adriano G. Arguedas and Partha Bagchi and Dainius A. Balis and Jeffrey L. Blumer},
  journal={The Pediatric Infectious Disease Journal},
  year={2007},
  volume={26},
  pages={879-891}
}
Background: Fluoroquinolones, including levofloxacin, have not been recommended for use in children largely because studies in juvenile laboratory animals suggest there may be an increased risk of fluoroquinolone-associated cartilage lesions. A large prospective trial is needed to assess the risks associated with using levofloxacin in children. Objective: Assess the safety and tolerability of levofloxacin therapy in children based on observations for 1 year after therapy. Methods: Safety data… 

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