Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity.
@article{Hansch2000ComparativeQE, title={Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity.}, author={C. Hansch and S. McKarns and C. Smith and D. Doolittle}, journal={Chemico-biological interactions}, year={2000}, volume={127 1}, pages={ 61-72 } }
Phenol and 14 substituted-phenols were tested for their ability to impair epithelial cell membrane integrity in WB rat liver cells as determined by an increase in lactate dehydrogenase release. Two quantitative structure-activity relationship (QSAR) regression equations were developed which showed that separate mechanisms of phenolic cytotoxicity are important - nonspecific toxicity due to hydrophobicity and formation of phenoxyl radicals. The equations most predictive of phenol toxicity are… CONTINUE READING
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