Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity.

@article{Hansch2000ComparativeQE,
  title={Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity.},
  author={C. Hansch and S. McKarns and C. Smith and D. Doolittle},
  journal={Chemico-biological interactions},
  year={2000},
  volume={127 1},
  pages={
          61-72
        }
}
  • C. Hansch, S. McKarns, +1 author D. Doolittle
  • Published 2000
  • Chemistry, Medicine
  • Chemico-biological interactions
  • Phenol and 14 substituted-phenols were tested for their ability to impair epithelial cell membrane integrity in WB rat liver cells as determined by an increase in lactate dehydrogenase release. Two quantitative structure-activity relationship (QSAR) regression equations were developed which showed that separate mechanisms of phenolic cytotoxicity are important - nonspecific toxicity due to hydrophobicity and formation of phenoxyl radicals. The equations most predictive of phenol toxicity are… CONTINUE READING
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    References

    SHOWING 1-10 OF 21 REFERENCES
    Phenol toxicity in leukemia cells: a radical process?
    • 63
    Correlation between hydrophobicity of short-chain aliphatic alcohols and their ability to alter plasma membrane integrity.
    • 109
    • PDF
    Comparative QSAR: radical toxicity and scavenging. Two different sides of the same coin.
    • 12
    Cell proliferation in carcinogenesis.
    • 986