Comparative Proteomics of Tumor and Paired Normal Breast Tissue Highlights Potential Biomarkers in Breast Cancer.
@article{DaCosta2015ComparativePO, title={Comparative Proteomics of Tumor and Paired Normal Breast Tissue Highlights Potential Biomarkers in Breast Cancer.}, author={Gustavo G{\'o}es Da Costa and Talita Helen Bombardelli Gomig and Rodrigo Kaviski and Karla Santos Sousa and Caroline Kukolj and Rubens Silveira de Lima and C{\'i}cero de Andrade Urban and Iglenir Jo{\~a}o Cavalli and Enilze Maria de Souza Fonseca Ribeiro}, journal={Cancer genomics \& proteomics}, year={2015}, volume={12 5}, pages={ 251-61 } }
BACKGROUND/AIM
Breast cancer is the most common type of cancer among women worldwide, and about 57,000 new cases are expected for the Brazilian population in 2015. Elucidation of protein expression and modification is essential for the biological understanding, early diagnosis and therapeutics of breast cancer. The main objectives of the study are comparison between the proteome of tumor and paired non-tumor breast cancer tissues, describing all identified proteins, highlighting the ones most…
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References
SHOWING 1-10 OF 108 REFERENCES
Proteomic analysis of non-tumoral breast tissue.
- Biology, MedicineGenetics and molecular research : GMR
- 2011
Breast cancer is a complex and heterogeneous disease. In spite of the advances made in recent decades, a better understanding of the intrinsic mechanisms of this disease is crucial. The development…
Comparative proteome analysis of breast cancer and normal breast
- BiologyMolecular biotechnology
- 2005
Two-dimensional gel electrophoresis combined with mass spectrometry was used to analyze changes in the proteome of infiltrating ductal carcinoma compared to normal breast tissue, and proteomics offers a powerful methodology to detect the proteins that show different expression patterns in breast cancer tissue and may provide an accurate molecular classification.
Comparative proteomics of primary breast carcinomas and lymph node metastases outlining markers of tumor invasion.
- MedicineCancer genomics & proteomics
- 2015
Comparing the proteome profile of primary breast tumors against that of lymph node metastasis strengthens previous omics-based studies and support the validation of potential markers of tumor invasion and metastasis.
The Differential Expression of Aqueous Soluble Proteins in Breast Normal and Cancerous Tissues in Relation to Stage and Grade of Patients
- BiologyJournal of biomedicine & biotechnology
- 2010
A significant relationship between the expression of the proteins with the stage or grade of IDC can be established, which increases the usefulness of these proteins as biomarkers for IDC.
Comparative proteomic analysis of ductal breast carcinoma demonstrates an altered expression of chaperonins and cytoskeletal proteins.
- BiologyMolecular medicine reports
- 2013
The proteins which the authors observed to exhibit an altered expression in infiltrating ductal breast carcinoma may be exploited as novel targets for therapeutic interventions or represent novel diagnostic/prognostic markers for the early detection of aggressive tumors, particularly those with multridrug-resistant phenotypes during the earlier stages of the disease.
Proteomic analysis in human breast cancer: Identification of a characteristic protein expression profile of malignant breast epithelium
- Medicine, BiologyProteomics
- 2006
A proteomic analysis of matched normal and malignant epithelia from invasive breast carcinomas leads to a better understanding of oncogenesis at an operational level and helps to characterize the malignant phenotype of individual tumors, and thereby to identify novel targets for antineoplastic therapy.
Serum proteome profiling of primary breast cancer indicates a specific biomarker profile.
- Biology, MedicineOncology reports
- 2011
14 biomarkers whose combination detects breast cancer patients from non-cancer controls with a sensitivity of 89% and specificity of 67%.
Quantitative proteomic profiling of matched normal and tumor breast tissues.
- Biology, MedicineJournal of proteome research
- 2010
Proteomic analysis of breast cancer tissue has proven difficult due to its inherent histological complexity. This pilot study presents preliminary evidence for the ability to differentiate adenoma…
Proteomics of human breast ductal carcinoma in situ.
- BiologyCancer research
- 2002
Proteomic analysis of DCIS revealed differential expression patterns distinct from previous nucleic acid-based studies and identified new facets of the earliest stage of breast cancer progression.
Proteomic analysis of tissue samples in translational breast cancer research
- BiologyExpert review of proteomics
- 2014
This work critically appraises what has been achieved to date using proteomic technologies and brings forward novel strategies – based on the analysis of clinically relevant samples – that promise to accelerate the translation of basic discoveries into the daily breast cancer clinical practice.