Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions.

@article{Saei2018ComparativePO,
  title={Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions.},
  author={Amir Ata Saei and Pierre Sabatier and {\"U}lk{\"u} G{\"u}ler Tokat and Alexey L. Chernobrovkin and Mohammad Pirmoradian and Roman A. Zubarev},
  journal={Molecular & cellular proteomics : MCP},
  year={2018},
  volume={17 6},
  pages={
          1144-1155
        }
}
Chemotherapeutics cause the detachment and death of adherent cancer cells. When studying the proteome changes to determine the protein target and mechanism of action of anticancer drugs, the still-attached cells are normally used, whereas the detached cells are usually ignored. To test the hypothesis that proteomes of detached cells contain valuable… CONTINUE READING
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