Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance

  title={Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance},
  author={Xiulan Chen and Shimeng Xu and Shasha Wei and Yaqin Deng and Yiran Li and F. Yang and P. Liu},
  journal={Scientific Reports},
  • Xiulan Chen, Shimeng Xu, +4 authors P. Liu
  • Published 2016
  • Medicine
  • Scientific Reports
  • Accumulated studies demonstrate that saturated fatty acids (FAs) such as palmitic acid (PA) inhibit insulin signaling in skeletal muscle cells and monounsaturated fatty acids such as oleic acid (OA) reverse the effect of PA on insulin signaling. The detailed molecular mechanism of these opposite effects remains elusive. Here we provide a comparative proteomic study of skeletal myoblast cell line C2C12 that were untreated or treated with PA, and PA plus OA. A total of 3437 proteins were… CONTINUE READING
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