Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics

@article{Kwon2019ComparativePP,
  title={Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics},
  author={Oh Kwang Kwon and Yun-Sok Ha and Jun Nyung Lee and Sunjoo Kim and Hye Suk Lee and So Young Chun and Tae Gyun Kwon and Sangkyu Lee},
  journal={Cancer Genomics \& Proteomics},
  year={2019},
  volume={16},
  pages={273 - 286}
}
Background/Aim: Prostate cancer (PCa) is the most frequent cancer found in males worldwide. The aim of this study was to identify new biomarkers using mutated peptides for the prognosis and prediction of advanced PCa, based on proteogenomics. Materials and Methods: The tryptic peptides were analyzed by tandem mass tag-based quantitative proteomics. Proteogenomics were used to identify mutant peptides as novel biomarkers in advanced PCa. Results: Using a human database, increased levels of INTS7… 

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