Comparative Physical Properties of Hyaluronic Acid Dermal Fillers

@article{Kablik2009ComparativePP,
  title={Comparative Physical Properties of Hyaluronic Acid Dermal Fillers},
  author={Jeffrey J. Kablik and Gary Monheit and Li-ping Yu and Grace Chang and Julia Gershkovich},
  journal={Dermatologic Surgery},
  year={2009},
  volume={35},
  pages={302–312}
}
BACKGROUND Hyaluronic acid (HA) fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. [] Key MethodMETHODS AND MATERIALS Analytical methods were employed to generate data on the properties of various fillers. The measured physical properties were concentration, gel-to-fluid ratio, HA gel concentration, degree of HA modification, percentage of cross-linking, swelling, modulus, and particle size. RESULTS The results demonstrated that commercial fillers exhibit a…
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286 Citations
Highly Influential Citations
6
Background Citations
55
Methods Citations
8
Results Citations
1

286 Citations

Citation Type

Citation Type

Rheological evaluation of the physical properties of hyaluronic acid dermal fillers.
TLDR
This rheologic evaluation demonstrates that differences exist among the HA products tested including gel elasticity, viscosity, and the range and distribution of gel particle sizes.
Gel Properties of Hyaluronic Acid Dermal Fillers
TLDR
No differentiation in filler properties could be seen as a result of manufacturing process used, except that the nonanimal stabilized HA stabilization process resulted in products with high gel strength and a low degree of modification.
Practical Guidelines for Hyaluronic Acid Soft-Tissue Filler Use in Facial Rejuvenation.
TLDR
The findings provide a basis for selection guideline regarding rheological properties in facial rejuvenation and help physicians select the appropriate fillers for more predictable and sustainable results.
Basics of Dermal Filler Rheology
  • S. Pierre, S. Liew, A. Bernardin
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2015
TLDR
How rheology, the study of the flow of matter, can be used to help physicians differentiate between dermal fillers targeted to certain areas of the face is explained.
Biophysical and biological characterization of a new line of hyaluronan-based dermal fillers: A scientific rationale to specific clinical indications.
Rheologic and Physicochemical Properties Used to Differentiate Injectable Hyaluronic Acid Filler Products
TLDR
While rheologic and physicochemical characteristics can vary widely between products and the methods and measurements of these parameters are often difficult to correlate, G′ represents a useful and consistent parameter for product differentiation.
Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation
Hyaluronan Dermal Fillers: Efforts Towards a Wider Biophysical Characterization and the Correlation of the Biophysical Parameters to the Clinical Outcome
TLDR
Clinical outcomes showed the safety of the products and a perception of palpability well correlating with the cohesive/viscosity properties of the gels, and initial clinical observation indicated that gel biophysical properties allow for a reliable prediction of gel palpability, while in vitro data on gel stability cannot be related to the duration of the observed skin improvement.
Evaluation of the Rheologic and Physicochemical Properties of a Novel Hyaluronic Acid Filler Range with eXcellent Three-Dimensional Reticulation (XTR™) Technology
TLDR
Fillers manufactured with the novel eXcellent three-dimensional reticulation (XTR™) technology were shown to have characteristic rheological, crosslinking and biophysical factors that support the suitability of this filler range for certain patient profiles.
Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers
TLDR
The mechanical properties and the particle texturing feel of the fillers made from crosslinked HA microspheres suspended in noncrosslinked HA (1368 kDa) are successfully achieved, which are adequate for the filler.
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