Comparative Pharmacology of GP IIb/IIIa Antagonists

@article{Schroer2003ComparativePO,
  title={Comparative Pharmacology of GP IIb/IIIa Antagonists},
  author={Karsten Schroer and A. Algora Weber},
  journal={Journal of Thrombosis and Thrombolysis},
  year={2003},
  volume={15},
  pages={71-80}
}
GP IIb/IIIa antagonists are qualitatively different from classical antiplatelet agents, such as aspirin or clopidogrel. They do not inhibit platelet activation, i.e. intraplatelet signal generation or conduction but primarily act outside the platelet by competing with ligand (e.g. fibrinogen) binding that is essential for platelet bridging and aggregate formation. Three compounds are in clinical use: abciximab, an antibody fragment and two low-molecular weight compounds, tirofiban and… CONTINUE READING
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