Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

@inproceedings{OKell2017ComparativePO,
  title={Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?},
  author={Allison L. O’Kell and Clive Wasserfall and Brian Catchpole and L J Davison and R S Hess and Jake A Kushner and Mark A Atkinson},
  booktitle={Diabetes},
  year={2017}
}
Despite decades of research in humans and mouse models of disease, substantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type 1 diabetes. Furthermore, translation of therapies from preclinical efforts capable of delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify alternative animal models that reflect human disease. Canine insulin deficiency diabetes is, in some cases, considered to follow autoimmune… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Herein , we consider the potential for canine diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathology , impairment of β-cell function and mass , islet inflammation ( i.e. , insulitis ) , and autoantibodies specific for β-cell antigens .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Also similar to human type 1 diabetes , the canonical canine disorder appears to be increasing in prevalence .
Also similar to human type 1 diabetes , the canonical canine disorder appears to be increasing in prevalence .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
Comparative Pathogenesis of Autoimmune Diabetes in Humans , NOD Mice , and Canines : Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked ? .
All Topics

Statistics

0102020172018
Citations per Year

Citation Velocity: 6

Averaging 6 citations per year over the last 2 years.

Learn more about how we calculate this metric in our FAQ.