Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1.

@article{Cook2011ComparativeNS,
  title={Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1.},
  author={Gabriel A. Cook and Hua Zhang and Sang Ho Park and Y Andrew Wang and Stanley J. Opella},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1808 2},
  pages={554-60}
}
The p7 protein from hepatitis C virus and the Vpu protein from HIV-1 are members of the viroporin family of small viral membrane proteins. It is essential to determine their structures in order to obtain an understanding of their molecular mechanisms and to develop new classes of anti-viral drugs. Because they are membrane proteins, it is challenging to study them in their native phospholipid bilayer environments by most experimental methods. Here we describe applications of NMR spectroscopy to… CONTINUE READING

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