• DOI:10.1124/MOL.105.015982
Corpus ID: 15678338

Comparative Models of GABAA Receptor Extracellular and Transmembrane Domains: Important Insights in Pharmacology and Functions⃞

@article{Ernst2005ComparativeMO,
  title={Comparative Models of GABAA Receptor Extracellular and Transmembrane Domains: Important Insights in Pharmacology and Functions⃞},
  author={M. Ernst and S. Bruckner and S. Boresch and W. Sieghart},
  journal={Molecular Pharmacology},
  year={2005},
  volume={68},
  pages={1291 - 1300}
}

M. Ernst, S. Bruckner, +1 author W. Sieghart

Published 2005

Chemistry, Medicine

Molecular Pharmacology

Comparative models of the extracellular and transmembrane domains of GABAA receptors in the agonist-free state were generated based on the recently published structures of the nicotinic acetylcholine receptor. The models were validated by computational methods, and their reliability was estimated by analyzing conserved and variable elements of the cys-loop receptor topology. In addition, the methodological limits in the interpretation of such anion channel receptor models are discussed… CONTINUE READING

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