Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar-/- Mice.

@article{Clancy2018ComparativeHL,
  title={Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar-/- Mice.},
  author={Chad S Clancy and Arnaud J Van Wettere and Venkatraman Siddharthan and John D. Morrey and Justin G Julander},
  journal={The American journal of pathology},
  year={2018},
  volume={188 4},
  pages={904-915}
}
An understanding of the pathogenesis of infection with the Zika virus in the male reproductive tract is vital for the development of vaccines and antivirals that will limit or prevent sexual transmission. Two common immunocompromised mouse strains used in transmission studies-male with genes encoding interferon types I and II receptor gene knockout (IFNAR/IFNGR; AG129) and with interferon type 1 receptor knockout (Ifnar-/-) were infected with a Puerto Rican Zika virus isolate (PRVABC59), and… CONTINUE READING
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