Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

@article{Ormerod2013ComparativeGO,
  title={Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence},
  author={Kate L Ormerod and Carl A. Morrow and Eve W L Chow and I. Russel Lee and Samantha D. M. Arras and Horst Joachim Schirra and Gary M. Cox and Bettina C. Fries and James Angus Fraser},
  journal={G3: Genes|Genomes|Genetics},
  year={2013},
  volume={3},
  pages={675 - 686}
}
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality among the human immunodeficiency virus/acquired immunodeficiency syndrome population and is known for frequently causing life-threatening relapses. To investigate the potential contribution of in-host microevolution to persistence and relapse, we have analyzed two serial isolates obtained from a patient with acquired immunodeficiency syndrome who suffered an initial and relapse episode of cryptococcal… 
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TLDR
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TLDR
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The data suggest that dormant yeast cells could exist in vitro and in vivo, and C. neoformans exhibits a huge plasticity and adaptation to hosts that deserves further study.
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