Comparative Genomics of Natural Killer Cell Receptor Gene Clusters

  title={Comparative Genomics of Natural Killer Cell Receptor Gene Clusters},
  author={James C. Kelley and Lutz Walter and John Trowsdale},
  journal={PLoS Genetics},
  pages={363 - 374}
Many receptors on natural killer (NK) cells recognize major histocompatibility complex class I molecules in order to monitor unhealthy tissues, such as cells infected with viruses, and some tumors. Genes encoding families of NK receptors and related sequences are organized into two main clusters in humans: the natural killer complex on Chromosome 12p13.1, which encodes C-type lectin molecules, and the leukocyte receptor complex on Chromosome 19q13.4, which encodes immunoglobulin superfamily… CONTINUE READING


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