Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex

@inproceedings{Sistrom2014ComparativeGR,
  title={Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex},
  author={Mark J. Sistrom and Benjamin R Evans and Robert D. Bjornson and Wendy Gibson and Oliver Balmer and Pascal M{\"a}ser and Serap Aksoy and Adalgisa Caccone},
  booktitle={Genome biology and evolution},
  year={2014}
}
The Trypanosoma brucei complex contains a number of subspecies with exceptionally variable life histories, including zoonotic subspecies, which are causative agents of human African trypanosomiasis (HAT) in sub-Saharan Africa. Paradoxically, genomic variation between taxa is extremely low. We analyzed the whole-genome sequences of 39 isolates across the T. brucei complex from diverse hosts and regions, identifying 608,501 single nucleotide polymorphisms that represent 2.33% of the nuclear… CONTINUE READING

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