Comparative Genomic Analysis of Human and Chimpanzee Indicates a Key Role for Indels in Primate Evolution

@article{Wetterbom2006ComparativeGA,
  title={Comparative Genomic Analysis of Human and Chimpanzee Indicates a Key Role for Indels in Primate Evolution},
  author={Anna Wetterbom and Marie Sevov and Lucia Cavelier and Tomas F. Bergstr{\"o}m},
  journal={Journal of Molecular Evolution},
  year={2006},
  volume={63},
  pages={682-690}
}
Sequence comparison of humans and chimpanzees is of interest to understand the mechanisms behind primate evolution. Here we present an independent analysis of human chromosome 21 and the high-quality BAC clone sequences of the homologous chimpanzee chromosome 22. In contrast to previous studies, we have used global alignment methods and Ensembl predictions of protein coding genes (n = 224) for the analysis. Divergence due to insertions and deletions (indels) along with substitutions was… 
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