Comparative Genetics of Functional Trinucleotide Tandem Repeats in Humans and Apes

Abstract

Several human neurodegenerative disorders are caused by the expansion of polymorphic trinucleotide repeat regions. Many of these loci are functional short tandem repeats (STRs) located in brain-expressed genes, and their study is thus relevant from both a medical and an evolutionary point of view. The aims of our study are to infer the comparative pattern… (More)
DOI: 10.1007/s00239-004-2628-5

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