Comparative Gene Expression Signature of Pig, Human and Mouse Induced Pluripotent Stem Cell Lines Reveals Insight into Pig Pluripotency Gene Networks

@article{Liu2013ComparativeGE,
  title={Comparative Gene Expression Signature of Pig, Human and Mouse Induced Pluripotent Stem Cell Lines Reveals Insight into Pig Pluripotency Gene Networks},
  author={Yajun Liu and Yangyang Ma and Jeong-Yeh Yang and De Cheng and Xiaopeng Liu and Xiaoling Ma and Franklin D. West and Huayan Amy Wang},
  journal={Stem Cell Reviews and Reports},
  year={2013},
  volume={10},
  pages={162-176}
}
Reported pig induced pluripotent stem cells (piPSCs) have shown either a bFGF-dependent state with human embryonic stem cell (ESC) and mouse epiblast stem cell (EpiSC) morphology and molecular features or piPSCs exist in a LIF-dependent state and resemble fully reprogrammed mouse iPSCs. The features of authentic piPSCs and molecular events during the reprogramming are largely unknown. In this study, we assessed the transcriptome profile of multiple piPSC lines derived from different… CONTINUE READING

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