Comparative Gene Expression Profiling of P. falciparum Malaria Parasites Exposed to Three Different Histone Deacetylase Inhibitors

@inproceedings{Andrews2012ComparativeGE,
  title={Comparative Gene Expression Profiling of P. falciparum Malaria Parasites Exposed to Three Different Histone Deacetylase Inhibitors},
  author={Katherine T. Andrews and Archna P. Gupta and Thanh Ngoc Tran and David P. Fairlie and Geoffrey N. Gobert and Zbynek Bozdech},
  booktitle={PloS one},
  year={2012}
}
Histone deacetylase (HDAC) inhibitors are being intensively pursued as potential new drugs for a range of diseases, including malaria. HDAC inhibitors are also important tools for the study of epigenetic mechanisms, transcriptional control, and other important cellular processes. In this study the effects of three structurally related antimalarial HDAC inhibitors on P. falciparum malaria parasite gene expression were compared. The three hydroxamate-based compounds, trichostatin A (TSA… CONTINUE READING

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