Comparative Expression of the Mitotic Regulators SAK and PLK in Colorectal Cancer

@article{Macmillan2001ComparativeEO,
  title={Comparative Expression of the Mitotic Regulators SAK and PLK in Colorectal Cancer},
  author={Jennifer C. Macmillan and John W Hudson and Shelley B. Bull and James W. Dennis and Carol Jane Swallow},
  journal={Annals of Surgical Oncology},
  year={2001},
  volume={8},
  pages={729-740}
}
AbstractBackground: Disruption of normal mechanisms for cell cycle regulation is important in carcinogenesis. SAK and PLK are members of the polo family of serine threonine kinases, which in lower organisms have been shown to be required for the precise regulation of mitosis. Studies of human polo family members have focused on PLK, which has been found to be overexpressed in several tumor types, with the degree of overexpression correlating with adverse clinical outcome. However, PLK… 

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