Comparative Evolutionary Analysis of Metabolism in Nine Drosophila Species.

  title={Comparative Evolutionary Analysis of Metabolism in Nine Drosophila Species.},
  author={Andrew G. Clark and Lei Wang},
  journal={Evolution; international journal of organic evolution},
  volume={48 4},
To attain balanced and efficient metabolism, the genes encoding enzymes involved in intermediary metabolism must be coordinately regulated. Gross misregulation of these genes can result in deleterious metabolic imbalances, as seen in transgenic laboratory organisms with altered gene dosage. By quantifying the expression of enzymes in nine related species of Drosophila, we hoped to see patterns of coordinated changes that could be related to evolutionary constraints on regulation. The storage… CONTINUE READING


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