Comparative Electrophysiology of Lorcainide and Norlorcainide in the Dog

  title={Comparative Electrophysiology of Lorcainide and Norlorcainide in the Dog},
  author={D. Keefe and R. Kates and R. Winkle},
  journal={Journal of Cardiovascular Pharmacology},
  • D. Keefe, R. Kates, R. Winkle
  • Published 1984
  • Medicine
  • Journal of Cardiovascular Pharmacology
  • Electrophysiologic effects of intravenous lorcainide and its major metabolite, norlorcainide, were examined in 18 anesthetized dogs, using intracardiac electrophysiologic measurements and programmed stimulation. Lorcainide and norlorcainide were studied separately, using six dogs for each experiment. Each compound was administered by a series of 5 one-h graded infusions each involving a loading dose over 15 min followed by a 45-min maintenance infusion. Plasma concentrations ranged from 94 ± 34… CONTINUE READING
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