Comparative Efficiency of HIV-1-Infected T Cell Killing by NK Cells, Monocytes and Neutrophils

  title={Comparative Efficiency of HIV-1-Infected T Cell Killing by NK Cells, Monocytes and Neutrophils},
  author={Adjoa Smalls-Mantey and M. Connors and Q. Sattentau},
  journal={PLoS ONE},
  • Adjoa Smalls-Mantey, M. Connors, Q. Sattentau
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • HIV-1 infected cells are eliminated in infected individuals by a variety of cellular mechanisms, the best characterized of which are cytotoxic T cell and NK cell-mediated killing. An additional antiviral mechanism is antibody-dependent cellular cytotoxicity. Here we use primary CD4+ T cells infected with the BaL clone of HIV-1 as target cells and autologous NK cells, monocytes, and neutrophils as effector cells, to quantify the cytotoxicity mediated by the different effectors. This was carried… CONTINUE READING
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