Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia

@article{Watt2019ComparativeEO,
  title={Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia},
  author={J. Watt and Z. Goodarzi and A. Veroniki and Vera Nincic and P. Khan and M. Ghassemi and Yuan Thompson and A. Tricco and S. Straus},
  journal={Annals of Internal Medicine},
  year={2019},
  volume={171},
  pages={633-642}
}
Dementia, which affects 50 million people worldwide, is characterized by progressive and deleterious effects on cognition and function (1, 2). As many as 75% of persons with dementia experience neuropsychiatric (behavioral and psychological) symptoms, including aggression, agitation, and anxiety (3, 4). Compared with those who do not have neuropsychiatric symptoms, these persons are institutionalized earlier and have poorer ability to complete activities of daily living (ADLs), greater… Expand
Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: State of the Art and Future Progress
TLDR
Current knowledge of the management of BPSD and its limitations is reviewed and on-going clinical trials and future therapeutic options are discussed. Expand
Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis
TLDR
Although antipsychotics were associated with greater harm than antidepressants and anticonvulsants in subgroups of persons with dementia, medications used in lieu of antipsychotic for treating neuropsychiatric symptoms in dementia, such as anticonVulsants and dextromethorphan-quinidine, were also associated with harm. Expand
Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis
TLDR
In this systematic review, non-drug interventions were found to be more efficacious than drug interventions for reducing symptoms of depression in people with dementia without a major depressive disorder. Expand
Strategies and interventions to reduce or manage refusals in personal care in dementia: A systematic review.
TLDR
Some non-pharmacological interventions can reduce, but not eliminate, refusals of care, such as playing music during care or communicating positively without using elderspeak, as well as Namaste Care or distraction techniques. Expand
2020 Alzheimer's disease facts and figures
  • Medicine
  • Alzheimer's & dementia : the journal of the Alzheimer's Association
  • 2020
TLDR
The future challenges of meeting care demands for the growing number of people living with Alzheimer's dementia in the United States with a particular emphasis on primary care are discussed, including recommendations for maximizing quality care in the face of the shortage of specialists and training challenges in primary care. Expand
The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease
  • Xiangyu Zhou, Lin Zhang
  • Medicine
  • Oxidative medicine and cellular longevity
  • 2021
The increasing numbers of elderly Alzheimer's disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewerExpand
Guidance for appropriate use of psychotropic drugs in older people
TLDR
The appropriateness of using psychotropic drugs in older people in terms of different aspects such as indications, contraindications, dosing, adverse drug reactions, interactions and duration of therapy is discussed. Expand
From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression
TLDR
It is proposed that unraveling the specific role of MAO in aggression requires an integrated approach, where this question is pursued by combining psychological, radiological, and genetic/genomic assessments and the discovery of novel biomarkers of aggression and targeting the MAO system to modulate pathological aggression in clinical populations. Expand
Take the First-Person Perspective to Become Dementia-Friendly: The Use of 360° Video for Experiencing Everyday-Life Challenges With Cognitive Decline
TLDR
It is possible to conclude that, through the change of perspective, people are more willing to be inclusive toward people with dementia, as is wished for in the DFC approach, although a wider formative intervention on how to be really inclusive still seems to be required. Expand
Introducing virtual reality therapy for inpatients with dementia admitted to an acute care hospital: learnings from a pilot to pave the way to a randomized controlled trial
TLDR
Overall, patients with dementia appear to tolerate immersive VR, and with suggested protocol alterations, it is feasible to evaluate this non-pharmacological intervention in acute care hospitals. Expand
...
1
2
...

References

SHOWING 1-10 OF 45 REFERENCES
Efficacy and Tolerability of Risperidone, Yokukansan, and Fluvoxamine for the Treatment of Behavioral and Psychological Symptoms of Dementia: A Blinded, Randomized Trial
TLDR
Risperidone, yokukansan or fluvoxamine for BPSD showed a more favorable profile in tolerability compared with risperid one, however, ykukansa or fluVoxamine showed a less favorable profile than ris peridone in terms of tolerability. Expand
The response of agitated behavior to pain management in persons with dementia.
TLDR
It was found that verbal agitation behaviors such as complaining, negativism, repetitious sentences and questions, constant request for attention, and cursing or verbal aggression responded to pain treatment, and restlessness and pacing were sensible to analgesics. Expand
Antipsychotic Drug Use and Mortality in Older Adults with Dementia
TLDR
This large, population-based study from Canada assessed the risk for death after dispensation of antipsychotics in older adults with dementia and concluded that improvements in behavioral symptoms with antipsychotic drug treatment do not necessarily lead to improvements in overall quality of life for patients or their caregivers. Expand
Comparative efficacy and safety of therapy for the behavioral and psychological symptoms of dementia: a systemic review and Bayesian network meta-analysis
TLDR
Aripiprazole, haloperidol, quetiapine, and risperidone of antipsychotics showed the significant efficacy, while memantine, galantine, and donepezil may provide the modest effectiveness. Expand
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study.
TLDR
These are the first population-based estimates for neuropsychiatric symptoms in MCI, indicating a high prevalence associated with this condition as well. Expand
The Neuropsychiatric Inventory
TLDR
The NPI is a useful instrument for characterizing the psychopathology of dementia syndromes, investigating the neurobiology of brain disorders with neuropsychiatric manifestations, distinguishing among different dementia syndromees, and assessing the efficacy of treatment. Expand
Comparative safety and efficacy of pharmacological and non-pharmacological interventions for the behavioral and psychological symptoms of dementia: protocol for a systematic review and network meta-analysis
TLDR
The safest and most efficacious treatment strategies for patients with BPSD will be identified from among the authors' most highly ranked treatments from among the published and unpublished literature. Expand
Discontinuation of antidepressants in people with dementia and neuropsychiatric symptoms (DESEP study): double blind, randomised, parallel group, placebo controlled trial
TLDR
Discontinuation of antidepressant treatment in patients with dementia and neuropsychiatric symptoms leads to an increase in depressive symptoms, compared with those patients who continue with treatment. Expand
Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia
TLDR
It is suggested that a single most effective and safe treatment option for people with dementia may not exist, and insufficient evidence exists on which atypical antipsychotic is both safest and most beneficial across several measures. Expand
Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX)
TLDR
Regular, long-term exercise intervention did not decrease NPS in patients with AD. Expand
...
1
2
3
4
5
...