Comparative Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and Serotonin‐Norepinephrine Reuptake Inhibitors in Older Adults: A Network Meta‐Analysis

  title={Comparative Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and Serotonin‐Norepinephrine Reuptake Inhibitors in Older Adults: A Network Meta‐Analysis},
  author={Kristian Thorlund and Eric F Druyts and Ping Wu and Chakrapani Balijepalli and Denis J. Keohane and Edward J. Mills},
  journal={Journal of the American Geriatrics Society},
  pages={1002 - 1009}
To establish the comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin‐norepinephrine reuptake inhibitors in older adults using the network meta‐analysis approach. 
Comparison of vortioxetine and sertraline for treatment of major depressive disorder in elderly patients: A double‐blind randomized trial
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Neuropsychiatric Properties of the ACE2/Ang-(1-7)/Mas Pathway: A Brief Review.
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SSRIs and TCAs are both associated with adverse effects, although the key effects differ between the drug classes, and there were no statistically significant differences between drug classes in terms of drop-outs due to adverse effects.
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The literature on the extent to which the elderly are represented in clinical trials of potential antidepressants is reviewed, with a focus on studies employing young adults and healthy elderly.
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Continuing treatment with antidepressants in elderly patients is efficacious compared with placebo in preventing relapses and recurrences and Efficacy and tolerability during long-term treatment does not differ between TCAs and SSRIs.
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Ant antidepressants are more effective than placebo in elderly depressed subjects although effects are modest and vary, and Identification of the characteristics of responders and nonresponders will be crucial to improving treatment outcomes.
Fluoxetine Versus Trazodone in Depressed Geriatric Patients
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Comparison of the tolerability and efficacy of citalopram and amitriptyline in elderly depressed patients treated in general practice
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Paroxetine CR and parxetine IR are effective and well tolerated treatments for major depressive disorder in elderly patients, including those with chronic depression.
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A routine treatment procedure that includes risk-factor identification, a thorough drug history, patient and caregiver education on compliance, and use of the lowest effective dose can help clinicians effectively manage elderly patients and limit the risk of adverse drug reactions.