Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters

@article{Kokkotou2008ComparativeEO,
  title={Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters},
  author={Efi G Kokkotou and Alan C. Moss and A Michos and Daniel G. Espinoza and Jeffrey Cloud and Nasima Mustafa and Michael O'brien and Charalabos Pothoulakis and Ciaran Kelly},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 3},
  pages={
          1121-6
        }
}

• Efi G Kokkotou, Alan C. Moss, +6 authors Ciaran Kelly
• Published 2008 in Antimicrobial agents and chemotherapy
• DOI:10.1128/AAC.01143-07

Clostridium difficile-associated colitis is an increasing cause of morbidity and mortality in hospitalized patients, with high relapse rates following conventional therapy. We sought to determine the efficacy of rifaximin, a novel nonabsorbed antibiotic, in the hamster model of C. difficile-associated diarrhea (CDAD). Hamsters received clindamycin subcutaneously and 24 h later were infected by gavage with one of two C. difficile strains: a reference strain (VPI 10463) and a current epidemic… CONTINUE READING

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