Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters

@article{Kokkotou2008ComparativeEO,
  title={Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters},
  author={Efi G Kokkotou and Alan C. Moss and A Michos and Daniel G. Espinoza and Jeffrey Cloud and Nasima Mustafa and Michael O'brien and Charalabos Pothoulakis and Ciaran Kelly},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 3},
  pages={
          1121-6
        }
}
Clostridium difficile-associated colitis is an increasing cause of morbidity and mortality in hospitalized patients, with high relapse rates following conventional therapy. We sought to determine the efficacy of rifaximin, a novel nonabsorbed antibiotic, in the hamster model of C. difficile-associated diarrhea (CDAD). Hamsters received clindamycin subcutaneously and 24 h later were infected by gavage with one of two C. difficile strains: a reference strain (VPI 10463) and a current epidemic… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 42 references

An epidemic, toxin gene-variant strain of Clostridium difficile.

The New England journal of medicine • 2005
View 7 Excerpts
Highly Influenced

In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004

C. Schriever, M. Galang, C. P. Kelly
Antimicrob . Agents Chemother . • 2007