Comparative Effects of Khellin and Timefurone on Serum Parameters in Normal Male Cynomolgus Monkeys

@article{Stevens1985ComparativeEO,
  title={Comparative Effects of Khellin and Timefurone on Serum Parameters in Normal Male Cynomolgus Monkeys},
  author={T. Stevens and W. A. Phillips and C. E. Day},
  journal={Journal of Medical Primatology},
  year={1985},
  volume={14}
}
  • T. Stevens, W. A. Phillips, C. E. Day
  • Published 1985
  • Biology, Medicine
  • Journal of Medical Primatology
    • Timefurone and khellin (10 mg/kg/day, gavage, 14 days) significantly lowered low density lipoprotein cholesterol, high density lipoprotein cholesterol, and total cholesterol. Khellininduced changes were significantly greater than those induced by timefurone. Neither drug altered body weights or clinical chemistry parameters. Monkeys treated with khellin, however, exhibited elevated levels of very low density lipoprotein cholesterol and marked emesis, while no changes were observed with… CONTINUE READING
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