Comparative Effects of Diet-Induced Lipid Lowering Versus Lipid Lowering Along With Apo A-I Milano Gene Therapy on Regression of Atherosclerosis

  title={Comparative Effects of Diet-Induced Lipid Lowering Versus Lipid Lowering Along With Apo A-I Milano Gene Therapy on Regression of Atherosclerosis},
  author={Lai Wang and Fang Tian and Ana Arias and Mingjie Yang and Behrooz G Sharifi and Prediman K Shah},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  pages={320 - 328}
  • Lai Wang, Fang Tian, P. Shah
  • Published 1 May 2016
  • Biology, Medicine
  • Journal of Cardiovascular Pharmacology and Therapeutics
Apolipoprotein A-1 (Apo A-I) Milano, a naturally occurring Arg173 to Cys mutant of Apo A-1, has been shown to reduce atherosclerosis in animal models and in a small phase 2 human trial. We have shown the superior atheroprotective effects of Apo A-I Milano (Apo A-IM) gene compared to wild-type Apo A-I gene using transplantation of retrovirally transduced bone marrow in Apo A-I/Apo E null mice. In this study, we compared the effect of dietary lipid lowering versus lipid lowering plus Apo A-IM… 

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