Comparative DNA adduct formation and induction of colonic aberrant crypt foci in mice exposed to 2-amino-9H-pyrido[2,3-b]indole, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, and azoxymethane.

Abstract

Considerable evidence suggests that environmental factors, including diet and cigarette smoke, are involved in the pathogenesis of colon cancer. Carcinogenic nitroso compounds (NOC), such as N-nitrosodimethylamine (NDMA), are present in tobacco and processed red meat, and NOC have been implicated in colon cancer. Azoxymethane (AOM), commonly used for… (More)
DOI: 10.1002/em.21993

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@article{Kim2016ComparativeDA, title={Comparative DNA adduct formation and induction of colonic aberrant crypt foci in mice exposed to 2-amino-9H-pyrido[2,3-b]indole, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, and azoxymethane.}, author={Sangyub Kim and Jingshu Guo and Marjorie O'Sullivan and Daniel D. Gallaher and Robert J Turesky}, journal={Environmental and molecular mutagenesis}, year={2016}, volume={57 2}, pages={125-36} }