Comparative Characterization of Glutamate Decarboxylase in Crude Homogenates of Oviduct, Ovary, and Hypothalamus

@article{Erd1984ComparativeCO,
  title={Comparative Characterization of Glutamate Decarboxylase in Crude Homogenates of Oviduct, Ovary, and Hypothalamus},
  author={S{\'a}ndor L. Erdő and B{\'e}la Kiss and L{\'a}szl{\'o} Szporny},
  journal={Journal of Neurochemistry},
  year={1984},
  volume={43}
}
Some biochemical characteristics of l‐glutamate decarboxylase (GAD) were compared using crude homogenates of the rat oviduct, ovary, and hypothalamus. As estimated by the measurement of CO2 production, the specific activities of oviductal and ovarian GAD were about 10 and 3% of the hypothalamic value, respectively. Stoichiometric formation of γ‐aminobutyric acid (GABA) and CO2 from l‐glutamate could be observed in oviduct and hypothalamus, while in ovarian homogenates the production of C02 was… 
22 Citations
Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: Further evidence for non-neural GABA systems
TLDR
The occurrence of GAD immunoreactivity inside developing ovarian follicles including the oocyte may suggest a role for GABA related to follicular development and certain functions concerning the ovum.
Glutamate Decarboxylases in Nonneural Cells of Rat Testis and Oviduct: Differential Expression of GAD65 and GAD67
TLDR
The localization of brain GAD and GAD mRNAs in the mucosal epithelial cells of the oviduct and in spermatocytes and sperMatids of the testis shows that GAD is not limited to neurons and that GABA may have functions other than neurotransmission.
Postmortem increase of GABA levels in peripheral rat tissues: Prevention by 3-mercapto-propionic acid
  • S. Erdő
  • Biology, Medicine
    Journal of Neural Transmission
  • 2005
TLDR
Evidence is provided for the ability of the 3-MPA treatment used, to prevent the postmortem increase of not only cerebral, but also oviductal and ovarian GABA levels, and this procedure proved to be inadequate for fixation of GABA concentration in the kidney.
Segmental distribution and gestational changes of GABA-transaminase activity in the rat oviduct.
TLDR
The observed increase of GABA-transaminase activity in the Oviduct of the pregnant rat may be responsible for the reduced GABA levels in the oviduct during gestation; and the extraneuronal localization ofGABA-transamination activity does not seem to support the suggestion of a possible GABAergic innervation of the oVIDuct.
Gamma-aminobutyric acid in the genital tract of the rat during the oestrous cycle.
TLDR
The variations observed in the present paper suggest an involvement of GABA in reproductive physiology, and it is suggested that the source of ovarian GABA was not the oviduct.
Possible involvement of ovarian mechanisms other than estrogen-progesterone secretion in the regulation of glutamic acid decarboxylase activity of the rat fallopian tubes.
TLDR
The results show that the prepubertal rat oviduct possesses a GABA content and a GAD activity analogous to those of normal diestrous rats, indicating that tubes of prepu Herbert rats are able to form the neurotransmitter by means of specific decarboxylation of glutamate.
Light- and electron-microscopic visualization of γ-aminobutyric acid and GABA-transaminase in the oviduct of rats
TLDR
The findings indicate that the role of GABA in the oviduct is not related to neurotransmission but may be related to ciliary functions, and both GABA immunoreactivity and enzyme reactivity were found primarily in the tubal epithelium.
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TLDR
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TLDR
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TLDR
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