Comparative Central Nervous System Effects and Pharmacokinetics of Neu‐metoclopramide and Metoclopramide in Healthy Volunteers

@article{Rotmensch1997ComparativeCN,
  title={Comparative Central Nervous System Effects and Pharmacokinetics of Neu‐metoclopramide and Metoclopramide in Healthy Volunteers},
  author={H. Rotmensch and G. Mould and J. A. Sutton and S. Kilminster and C. Moller and R. Pero},
  journal={The Journal of Clinical Pharmacology},
  year={1997},
  volume={37}
}
  • H. Rotmensch, G. Mould, +3 authors R. Pero
  • Published 1997
  • Medicine
  • The Journal of Clinical Pharmacology
  • Metoclopramide, a drug used for the relief of nausea and emesis, is currently under development as a radio‐ and chemosensitizing agent. Its usefulness in high doses, however, is limited by its central nervous system side effects. Neu‐metoclopramide (Neu Sensamide), a novel, concentrated, phosphate‐buffered, pH‐adjusted (pH = 6.5–7.0) formulation of metoclopramide, has been shown to have an improved side‐effect profile in animal studies. The present double‐blind, four‐way crossover study… CONTINUE READING
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